Bioenergetic Engineering
Genetic engineering now lets us control life’s information, yet the engineering of life’s energy remains underdeveloped. A powerful set of new tools could bridge the gap, enabling breakthroughs ranging from treatments for neurodegenerative disease to biohybrid solutions for environmental remediation and resilience.
What is an opportunity space?
Opportunity spaces are areas of research that we believe are ripe for breakthroughs. They are defined by our Programme Directors, and must be highly consequential for society, under-explored relative to their potential impact, and ripe for new talent, perspectives, or resources to change what’s possible.
Core beliefs
The core beliefs that underpin this opportunity space:
While information has been the major focus of modern biology, energy and information are both fundamental to life → bioenergetic engineering has the potential to catalyse advances on the scale of the genetic revolution.
Life uses powerful energy building blocks, like ATP, that are unlike any used in engineering → leveraging these primitives will enable a range of bio-hybrid devices and other systems whose performance far exceeds today’s best designs.
The feedback loop between engineering disciplines and fresh insights is accelerating → we’re at an inflection point where scientists and engineers from many disciplines can begin treating life’s energy machinery as a design space.
Programme: Precision Mitochondria
ARIA is launching a programme backed by at least £55 million to make the mitochondrial genome programmable in vivo. For decades, mitochondria have remained the last major genome that cannot be readily engineered. This programme aims to create a foundational toolkit to overcome this long-standing challenge and transform mitochondrial biology.
The immediate goal is to achieve persistent, reproducible expression of a novel gene from engineered mitochondrial DNA (mtDNA) in a vertebrate system.
Meet the programme team
Our Programme Directors are supported by a core team that provides a blend of operational coordination and highly specialised technical expertise.
Nathan Wolfe
Programme Director
Nathan is a renowned virologist, epidemiologist, and entrepreneur. Most recently, he was a Visiting Scholar in Stanford's Bioengineering Department, having previously founded initiatives to quantify epidemic and pandemic risk, and coordinate scientists globally to spot emerging pathogens. He served on DARPA’s Defense Sciences Research Council.
Sarath Murugan
Programme Specialist
Sarath joined ARIA from a business operations and strategy role at a defence engineering scale-up, where his team developed a product that brought the capabilities of gen-AI to the disconnected-edge. He holds an LLB from Bristol, and has experience in project and product-facing roles. Sarath supports ARIA as an operating partner from Pace.
Ryan Olf
External Technical Advisor
Ryan is a Caltech and Berkeley-trained physicist with a varied and voracious technical appetite. His previous adventures include creating the world’s lowest-entropy quantum gas, designing nanotube-based GLP-1 implants, automating gene therapy manufacturing, and developing software for his family’s village shop.
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